Capcom gab die Musiker bekannt, die für den Soundtrack von DmC Devil May Cry in enger Zusammenarbeit mit Capcom und Ninja Theory verantwortlich zeichnen: Sowohl Noisia als auch Combichrist steuern Musik bei, die während der kinoreifen Zwischensequenzen und Gameplay – darunter auch Kampf-Passagen – zu hören sein werden. Ebenso wurden einige Tracks des Combichrist-Katalogs lizenziert, um darüber hinaus zu einem Spielsoundtrack beizutragen, der Spielern das Adrenalin durch die Adern pumpt.

“It’s been an awesome experience working with Ninja Theory on the game. We had great freedom but were also bound by certain criteria typical in the game world. These are challenging boundaries (for example; consistency in sonics over 180 minutes of music) but also lots of space in terms of dynamics & progression and instrumentation being able to create soundscapes without having to worry about holding the attention of a dancefloor. Their music director was great to work with, good vibes. It's great when you get to play to your strengths. Also, the game kicks ass! “ – Noisia, June 2012

“As an avid gamer myself I was honored to be asked to work on this project. I had a lot of fun digging myself into Dante’s psyche in order to create music to match the battle scenes and am equally as excited to license existing Combichrist music. I’m looking forward playing the finished game when it comes out.” - Andy LaPlegua, Lead Singer Combichrist, June 2012